WOLVERINE Bundle
The WOLVERINE Bundle is a three-vial tissue-repair research stack: BPC-157 10 mg, TB-500 5 mg and Ipamorelin 10 mg — three independently studied research tools, at 10% off the individual vial prices.
BPC-157 is a stable gastric pentadecapeptide studied in tendon-healing models, where it promoted fibroblast outgrowth, survival and migration[1], and in angiogenesis models, with pro-angiogenic activity associated with VEGFR2 activation[3]. TB-500 is synthetic full-length thymosin beta-4, an actin-regulating peptide that promoted cell migration and repair signalling in preclinical studies[5]. Ipamorelin is the first selective growth-hormone secretagogue described in the literature[7].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) research on these molecules and are provided as scientific reference for laboratory research only.
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Recovery Research Stack
Three Compounds, One Research Focus
The WOLVERINE Bundle combines three research peptides frequently used in tissue-repair and growth-hormone-axis studies. BPC-157 is a stable gastric pentadecapeptide documented in tendon-healing models, where it promoted tendon-fibroblast outgrowth, survival and migration[1], and in angiogenesis models, where its pro-angiogenic activity was associated with VEGFR2 activation[3]. TB-500 is synthetic full-length thymosin beta-4 — the 43-amino-acid peptide identified as a principal G-actin-sequestering molecule[6]. Ipamorelin completes the stack on the systemic side as the first selective growth-hormone secretagogue described in the literature[7].
- Three independently studied research pathways in one stack
- BPC-157 — tendon-healing and angiogenesis models
- TB-500 — full-length thymosin beta-4 (43 aa)
- Ipamorelin — selective growth-hormone secretagogue
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as three separate lyophilized vials: BPC-157 10 mg, TB-500 5 mg and Ipamorelin 10 mg. The pairing is deliberate: in preclinical models, BPC-157 and TB-500 have been studied on local repair pathways — fibroblast migration and actin dynamics — while Ipamorelin has been characterised on the growth-hormone axis via the GHRP (ghrelin) receptor[7], with a pharmacokinetic profile described in human volunteers[8].
- BPC-157 — 10 mg lyophilized vial
- TB-500 — 5 mg lyophilized vial
- Ipamorelin — 10 mg lyophilized vial
- Local repair signalling + growth-hormone-axis coverage
- 10% saving versus buying the three vials separately
Research Applications
Areas of Scientific Investigation
Each of the three compounds has been studied separately in repair-oriented research: in a rat model, BPC-157 accelerated healing of the transected Achilles tendon[2], while thymosin beta-4 — the molecule supplied as TB-500 — activated integrin-linked kinase and promoted cardiac cell migration, survival and repair[5]. No published study evaluates the three compounds in combination; researchers using them side by side are combining independent lines of evidence.
- Tendon, ligament and muscle injury models
- Wound-healing and angiogenesis assays
- Actin dynamics and cytoskeletal research
- Growth-hormone secretagogue signalling studies
Understanding the Wolverine Stack: Mechanism of Action
BPC-157 is a 15-amino-acid fragment of the Body Protection Compound found in gastric juice. In preclinical models it has been reported to promote tissue-repair signalling through several converging mechanisms: promotion of tendon-fibroblast outgrowth and migration, likely via the FAK–paxillin pathway[1], accelerated healing of transected tendon in a rat study[2], pro-angiogenic activity associated with VEGFR2 activation[3], and a documented relationship with the nitric-oxide system[4].
TB-500 is synthetic full-length thymosin beta-4 (43 amino acids), identified as a principal G-actin-sequestering peptide. Thymosin beta-4 binds monomeric G-actin and regulates its polymerisation[6] — the machinery cells use to move. In a 2004 Nature study, thymosin beta-4 activated integrin-linked kinase and promoted cardiac cell migration and survival after injury[5].
Ipamorelin is a pentapeptide described as the first selective growth-hormone secretagogue: in animal models it stimulated GH release via the GHRP (ghrelin) receptor without meaningfully raising cortisol or ACTH[7]. Its pharmacokinetics and GH-response dynamics have been modelled in human volunteers[8].
Together, the three compounds give researchers a three-pathway model of tissue repair: local angiogenic and cytoprotective signalling (BPC-157), cytoskeletal motility and actin regulation (TB-500), and systemic growth-hormone-axis signalling (Ipamorelin). Each pathway is supported by its own line of preclinical evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-80.
- Staresinic M, Sebecic B, Patrlj L, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;21(6):976-83.
- Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333.
- Sikiric P, Seiwerth S, Rucman R, et al. Stable gastric pentadecapeptide BPC 157-NO-system relation. Curr Pharm Des. 2014;20(7):1126-35.
- Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-72.
- Safer D, Elzinga M, Nachmias VT. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem. 1991;266(7):4029-32.
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61.
- Gobburu JV, Agerso H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-6.
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WOLVERINE Bundle
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$175.50$315.00
- ≥99%96%
- 3 vials3 vials
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