CLARITY Bundle
The CLARITY Bundle is a three-vial research set — two neuropeptides, Semax 5 mg and Selank 5 mg, plus the cofactor Vitamin B12 10 mg — at 10% off the individual vial prices.
Semax is an ACTH(4-10) analogue that regulated BDNF and TrkB expression in rat hippocampus studies[1]. Selank is a tuftsin-derived heptapeptide studied as a peptide anxiolytic[3], whose administration affected GABAergic gene expression[4]. Vitamin B12 is an essential cofactor in one-carbon metabolism[5].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) research and review literature on these molecules and are provided as scientific reference for laboratory research only.
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Cognitive Research Stack
Three Vials, One Research Focus
The CLARITY Bundle is built around neuropeptide research. Semax is a synthetic analogue of ACTH(4-10) studied for cognitive-related signalling: in rat hippocampus studies it regulated the expression of BDNF and its receptor TrkB[1]. Selank is a tuftsin-derived heptapeptide studied as a peptide anxiolytic at the molecular level[3]. Vitamin B12 completes the set as an essential cofactor in one-carbon metabolism[5].
- Neuropeptide and cofactor research in one set
- Semax — ACTH(4-10) analogue, BDNF research
- Selank — tuftsin-derived anxiolytic research peptide
- Vitamin B12 — essential metabolic cofactor
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as three separate lyophilized vials: Semax 5 mg, Selank 5 mg and Vitamin B12 10 mg. Each peptide carries its own documented line of evidence: in preclinical studies, Semax bound specifically in rat basal forebrain and increased levels of BDNF protein[2], while Selank administration affected the expression of genes involved in GABAergic neurotransmission[4].
- Semax — 5 mg lyophilized vial
- Selank — 5 mg lyophilized vial
- Vitamin B12 — 10 mg lyophilized vial
- BDNF, GABAergic and cofactor research angles
- 10% saving versus buying the three vials separately
Research Applications
Areas of Scientific Investigation
Each compound carries its own line of evidence: Semax regulated BDNF and TrkB expression in the rat hippocampus[1]; Selank's anxiolytic-related activity has been characterised at the molecular level[3]; and vitamin B12 biology, from deficiency states to trafficking chemistry, has been reviewed in depth[5][6]. No published study evaluates the compounds of this set in combination; researchers using them side by side are combining independent lines of evidence.
- BDNF and neurotrophin signalling research
- GABAergic neurotransmission studies
- Anxiolytic-peptide pharmacology models
- One-carbon metabolism and cofactor research
Understanding the Clarity Stack: Mechanism of Action
Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment. In rat hippocampus studies it regulated the expression of BDNF and its receptor TrkB[1], and in rat basal-forebrain studies it bound specifically and increased levels of BDNF protein[2] — the neurotrophin axis studied as an entry point into cognitive-signalling research.
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin. Its biological activity as a peptide anxiolytic has been characterised at the molecular level[3], and its administration affected the expression of genes involved in GABAergic neurotransmission[4].
Vitamin B12 (cobalamin) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase; its role in one-carbon metabolism and the consequences of its deficiency have been comprehensively reviewed[5], and the redox-linked coordination chemistry directing its intracellular trafficking has been characterised[6].
Together, the three vials give researchers a neurochemistry toolkit: neurotrophin signalling (Semax), GABAergic signalling (Selank) and cofactor chemistry (vitamin B12). Each is supported by its own line of preclinical evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60.
- Dolotov OV, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006;97 Suppl 1:82-86.
- Vyunova TV, et al. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914-923.
- Volkova A, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31.
- Green R, Allen LH, Bjorke-Monsen AL, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017;3:17040.
- Banerjee R, Gouda H, Pillay S. Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking. Acc Chem Res. 2021;54(8):2003-2013.
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CLARITY Bundle
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Prime
Lab PeptidesTypical
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$166.50$300.00
- ≥99%96%
- 3 vials3 vials
- Free 2-Day Shipping3-10 Business Day
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