KLOW MAX Bundle
The KLOW MAX Bundle is a three-vial skin-and-repair research stack: the Klow blend 80 mg (GHK-Cu + BPC-157 + TB-500 + KPV), a full BPC-157 10 mg vial and GHK-Cu 100 mg — at 10% off the individual vial prices.
GHK-Cu is the copper complex of a naturally occurring tripeptide, studied as a modulator of multiple cellular pathways in skin-regeneration research[7]. BPC-157 is a stable gastric pentadecapeptide studied in tendon-healing models, where it promoted fibroblast outgrowth, survival and migration[1]. TB-500, inside the blend, is synthetic full-length thymosin beta-4, an actin-regulating peptide that promoted cell migration and repair signalling in preclinical studies[6]. The blend also carries KPV, the C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory signalling[9].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) research on these molecules and are provided as scientific reference for laboratory research only.
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Skin Research Stack
Three Vials, One Research Focus
The KLOW MAX Bundle is built around skin-and-repair research. The Klow blend combines GHK-Cu, BPC-157, TB-500 and the tripeptide KPV in a single 80 mg vial, reinforced by a full-size GHK-Cu 100 mg vial — the copper complex of a naturally occurring tripeptide studied as a modulator of multiple cellular pathways in skin-regeneration research[7] — and a BPC-157 10 mg vial, a pentadecapeptide documented in tendon-healing models[1] and in angiogenesis models, with pro-angiogenic activity associated with VEGFR2 activation[3].
- Skin-and-repair research theme across three vials
- Klow blend — GHK-Cu, BPC-157, TB-500 and KPV in one vial
- GHK-Cu — copper tripeptide, skin and remodelling research
- BPC-157 — tendon-healing and angiogenesis models
- KPV — anti-inflammatory signalling research
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as three separate lyophilized vials: the Klow blend (80 mg), BPC-157 10 mg and GHK-Cu 100 mg. In preclinical models, GHK-Cu has been studied in skin and connective-tissue research[7], BPC-157 on fibroblast migration[1], and thymosin beta-4 — supplied as TB-500 inside the blend — in actin dynamics[5]. The blend adds KPV, the C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory signalling[9].
- Klow blend — 80 mg combination vial (GHK-Cu + BPC-157 + TB-500 + KPV)
- GHK-Cu — 100 mg lyophilized vial
- BPC-157 — 10 mg lyophilized vial
- Copper-peptide chemistry + peptide repair signalling
- 10% saving versus buying the three vials separately
Research Applications
Areas of Scientific Investigation
Each compound has been studied separately: GHK-Cu was described as a modulator of collagen synthesis and remodelling pathways in skin-regeneration research[7] and transiently improved healing outcome in a rat model of ACL reconstruction[8]; in a rat model, BPC-157 accelerated healing of the transected Achilles tendon[2]; and thymosin beta-4 activated integrin-linked kinase and promoted cardiac cell migration, survival and repair[6]. In preclinical models, PepT1-mediated uptake of the tripeptide KPV reduced intestinal inflammation[9]. No published study evaluates the three vials in combination; researchers using them side by side are combining independent lines of evidence.
- Skin-regeneration and remodelling research
- Collagen-synthesis and antioxidant-defence assays
- Wound-healing and angiogenesis assays
- Tendon, ligament and muscle injury models
- Anti-inflammatory signalling research
Understanding the Klow Max Stack: Mechanism of Action
GHK-Cu is the copper complex of glycyl-L-histidyl-L-lysine, a tripeptide naturally present in human plasma whose levels decline with age. It has been studied as a modulator of multiple cellular pathways in skin regeneration — collagen synthesis, extracellular-matrix remodelling and antioxidant defence[7] — and, in a rat model of ACL reconstruction, transiently improved healing outcome[8]. The bundle carries it twice: inside the Klow blend and as a full 100 mg vial.
BPC-157 is a 15-amino-acid fragment of the Body Protection Compound found in gastric juice. In preclinical models it has been reported to promote tissue-repair signalling through several converging mechanisms: promotion of tendon-fibroblast outgrowth and migration, likely via the FAK–paxillin pathway[1], accelerated healing of transected tendon in a rat study[2], pro-angiogenic activity associated with VEGFR2 activation[3], and a documented relationship with the nitric-oxide system[4].
TB-500, the third component of the Klow blend, is synthetic full-length thymosin beta-4 (43 amino acids), identified as a principal G-actin-sequestering peptide. Thymosin beta-4 binds monomeric G-actin and regulates its polymerisation[5]; in a 2004 Nature study, it activated integrin-linked kinase and promoted cardiac cell migration and survival after injury[6].
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, the fourth component of the Klow blend. In preclinical models, its PepT1-mediated cellular uptake reduced intestinal inflammation[9], and it is studied as an anti-inflammatory signalling tool alongside skin-research peptides.
Together, the three vials give researchers a skin-and-repair toolkit: copper-peptide chemistry (GHK-Cu, included twice), local repair signalling (BPC-157), actin regulation (thymosin beta-4) and anti-inflammatory signalling (KPV). Each pathway is supported by its own line of preclinical evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-80.
- Staresinic M, Sebecic B, Patrlj L, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;21(6):976-83.
- Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333.
- Sikiric P, Seiwerth S, Rucman R, et al. Stable gastric pentadecapeptide BPC 157-NO-system relation. Curr Pharm Des. 2014;20(7):1126-35.
- Safer D, Elzinga M, Nachmias VT. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem. 1991;266(7):4029-32.
- Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-72.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.
- Fu SC, Cheuk YC, Chiu WY, Yung SH, Rolf CG, Chan KM. Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction. J Orthop Res. 2015;33(7):1024-1033.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78.
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KLOW MAX Bundle
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Prime
Lab PeptidesTypical
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$288.00$520.00
- ≥99%96%
- 3 vials3 vials
- Free 2-Day Shipping3-10 Business Day
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