MITOFUEL Bundle
The MITOFUEL Bundle is a four-vial cellular-energy research stack: 2 × NAD+ 500 mg, MOTS-C 10 mg and Vitamin B12 10 mg — at 10% off the individual vial prices.
NAD+ is a coenzyme central to cellular energy metabolism, whose roles during ageing have been comprehensively reviewed[1]. MOTS-C is a mitochondrial-derived peptide that promoted metabolic homeostasis in mouse models[3]. Vitamin B12 is an essential cofactor in one-carbon metabolism[5].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) research and review literature on these molecules and are provided as scientific reference for laboratory research only.
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Cellular Energy Stack
Four Vials, One Research Focus
The MITOFUEL Bundle is built around cellular-energy research, with a double supply of NAD+ — the coenzyme at the centre of cellular energy metabolism, whose roles during ageing have been comprehensively reviewed[1] — alongside MOTS-C, a mitochondrial-derived peptide that promoted metabolic homeostasis in preclinical models[3], and Vitamin B12, an essential cofactor in one-carbon metabolism[5].
- Double NAD+ supply for extended research protocols
- NAD+ — coenzyme of cellular energy metabolism
- MOTS-C — mitochondrial-derived peptide research
- Vitamin B12 — essential metabolic cofactor
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as four separate lyophilized vials: two NAD+ 500 mg vials, MOTS-C 10 mg and Vitamin B12 10 mg. Declining NAD+ levels have been studied in ageing, metabolism and neurodegeneration research[2], while MOTS-c was shown to translocate to the nucleus to regulate nuclear gene expression under metabolic stress[4] — two complementary layers of mitochondrial research, completed by the cofactor chemistry of B12[6].
- NAD+ — 2 × 500 mg lyophilized vials
- MOTS-C — 10 mg lyophilized vial
- Vitamin B12 — 10 mg lyophilized vial
- Coenzyme + mitochondrial-peptide + cofactor coverage
- 10% saving versus buying the four vials separately
Research Applications
Areas of Scientific Investigation
Each compound carries its own line of evidence: NAD+ metabolism during ageing is the subject of a major review literature[1]; in mouse models, MOTS-c promoted metabolic homeostasis and reduced obesity and insulin resistance[3]; and vitamin B12 biology — from deficiency states to intracellular trafficking — has been characterised in depth[5][6]. No published study evaluates the four vials in combination; researchers using them side by side are combining independent lines of evidence.
- Cellular energy and coenzyme metabolism research
- Mitochondrial-peptide signalling studies
- One-carbon metabolism and cofactor research
- Ageing and metabolic-homeostasis models
Understanding the Mitofuel Stack: Mechanism of Action
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism and a required substrate for sirtuins and PARP enzymes. Its metabolism and roles in cellular processes during ageing have been comprehensively reviewed[1], and declining NAD+ levels have been studied in ageing, metabolism and neurodegeneration research[2].
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome. In preclinical models it promoted metabolic homeostasis and reduced obesity and insulin resistance in mice[3], and was shown to translocate to the nucleus to regulate nuclear gene expression in response to metabolic stress[4].
Vitamin B12 (cobalamin) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase; its role in one-carbon metabolism and the consequences of its deficiency have been comprehensively reviewed[5], and the redox-linked coordination chemistry directing its intracellular trafficking has been characterised[6].
Together, the four vials give researchers a cellular-energy toolkit: coenzyme biochemistry (NAD+, supplied twice), mitochondrial-peptide signalling (MOTS-c) and cofactor chemistry (vitamin B12). Each is supported by its own line of evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-13.
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
- Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018;28(3):516-524.e7.
- Green R, Allen LH, Bjorke-Monsen AL, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017;3:17040.
- Banerjee R, Gouda H, Pillay S. Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking. Acc Chem Res. 2021;54(8):2003-2013.
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MITOFUEL Bundle
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Prime
Lab PeptidesTypical
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$261.00$470.00
- ≥99%96%
- 4 vials4 vials
- Free 2-Day Shipping3-10 Business Day
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