SURGE Bundle
The SURGE Bundle is a three-vial growth-hormone-axis research stack: Grow-H 10 mg (CJC-1295 no DAC + Ipamorelin), Sermorelin 5 mg and Ipamorelin 10 mg — at 10% off the individual vial prices.
On the GHRH side, the long-acting form of CJC-1295 produced prolonged GH and IGF-I elevations in healthy adults[1] and Sermorelin is GHRH(1-29), which elicited growth-hormone responses in normal men[3]. On the secretagogue side, Ipamorelin is the first selective growth-hormone secretagogue described in the literature[5].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) and clinical research on these molecules and are provided as scientific reference for laboratory research only.
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GH-Axis Research Stack
Three Vials, One Research Axis
The SURGE Bundle concentrates entirely on the growth-hormone axis, probing it through its two receptor systems. On the GHRH side, Grow-H pairs CJC-1295 (no DAC), a GHRH(1-29) analogue — the long-acting form of CJC-1295 produced prolonged GH and IGF-I elevations in healthy adults[1] — and Sermorelin is GHRH(1-29) itself, which elicited growth-hormone responses in normal men[3]. On the secretagogue side, Ipamorelin is the first selective growth-hormone secretagogue described in the literature[5].
- One research axis probed through two receptor systems
- Grow-H — CJC-1295 (no DAC) and Ipamorelin in one vial
- Sermorelin — GHRH(1-29) fragment
- Ipamorelin — selective growth-hormone secretagogue
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as three separate lyophilized vials: Grow-H 10 mg (CJC-1295 no DAC + Ipamorelin), Sermorelin 5 mg and Ipamorelin 10 mg. The GHRH analogues and the secretagogue act on two different pituitary receptor systems — in a clinical study, pulsatile GH secretion persisted during continuous stimulation by long-acting CJC-1295[2], and Ipamorelin's pharmacokinetics were modelled in human volunteers[6].
- Grow-H — 10 mg combination vial (CJC-1295 no DAC + Ipamorelin)
- Sermorelin — 5 mg lyophilized vial
- Ipamorelin — 10 mg lyophilized vial
- GHRH-receptor + GHRP (ghrelin) receptor coverage
- 10% saving versus buying the three vials separately
Research Applications
Areas of Scientific Investigation
Each compound carries its own line of evidence: the long-acting form of CJC-1295 produced prolonged GH and IGF-I elevations in healthy adults[1]; sermorelin was reviewed for use in the diagnosis and treatment of idiopathic growth-hormone deficiency in children[4]; and in animal models Ipamorelin stimulated GH release via the GHRP (ghrelin) receptor, and in swine it did not meaningfully raise cortisol or ACTH[5]. No published study evaluates the compounds of this set in combination; researchers using them side by side are combining independent lines of evidence.
- Growth-hormone axis and pituitary signalling studies
- GHRH-receptor pharmacology research
- Ghrelin-receptor secretagogue research
- Pulsatility and GH-release dynamics models
Understanding the Surge Stack: Mechanism of Action
The stack works through two complementary pituitary receptor systems. CJC-1295 (no DAC), the GHRH(1-29) analogue in Grow-H, targets GHRH receptors: in healthy adults, the long-acting form of CJC-1295 produced prolonged elevations of GH and IGF-I[1], and pulsatile GH secretion persisted during continuous stimulation[2].
Sermorelin doubles down on the same receptor: it is GHRH(1-29) itself, the shortest fully active fragment of growth-hormone-releasing hormone. In normal men it elicited growth-hormone responses[3], and it was later reviewed for use in the diagnosis and treatment of idiopathic growth-hormone deficiency in children[4].
Ipamorelin — present both inside Grow-H and as its own 10 mg vial — engages the second system: it is a pentapeptide described as the first selective growth-hormone secretagogue, and in animal models it stimulated GH release via the GHRP (ghrelin) receptor — in swine without meaningfully raising cortisol or ACTH[5]. Its pharmacokinetics and GH-response dynamics have been modelled in human volunteers[6].
Together, the three vials give researchers a single-axis, dual-receptor model of growth-hormone signalling: GHRH-receptor stimulation (CJC-1295 no DAC, sermorelin) alongside GHRP/ghrelin-receptor stimulation (ipamorelin). Each is supported by its own line of evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805.
- Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797.
- Barron JL, Coy DH, Millar RP. Growth hormone responses to growth hormone-releasing hormone (1-29)-NH2 and a D-Ala2 analog in normal men. Peptides. 1985;6(3):575-577.
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157.
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61.
- Gobburu JV, Agerso H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-6.
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SURGE Bundle
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$207.00$375.00
- ≥99%96%
- 3 vials3 vials
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