PRIME Bundle
The PRIME Bundle is a three-vial ageing-biology research stack: NAD+ 500 mg, MOTS-C 10 mg and Sermorelin 5 mg — at 10% off the individual vial prices.
NAD+ is a coenzyme central to cellular energy metabolism, whose roles during ageing have been comprehensively reviewed[1]. MOTS-C is a mitochondrial-derived peptide described as an exercise-induced regulator of muscle homeostasis in mice[4]. Sermorelin is GHRH(1-29), the shortest fully active fragment of growth-hormone-releasing hormone[5][6].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) and clinical research on these molecules and are provided as scientific reference for laboratory research only.
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Longevity Research Stack
Three Vials, Three Research Angles
The PRIME Bundle is built around ageing-biology research. NAD+ is the coenzyme at the centre of cellular energy metabolism, whose roles during ageing have been comprehensively reviewed[1]. MOTS-C is a mitochondrial-derived peptide described as an exercise-induced regulator of age-dependent physical decline in mice[4]. Sermorelin is GHRH(1-29), the shortest fully active fragment of growth-hormone-releasing hormone[5][6].
- Ageing-biology research across three pathways
- NAD+ — coenzyme of cellular energy metabolism
- MOTS-C — mitochondrial-derived peptide research
- Sermorelin — GHRH(1-29) fragment, GH-axis research
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as three separate lyophilized vials: NAD+ 500 mg, MOTS-C 10 mg and Sermorelin 5 mg. The three compounds cover three layers of ageing research: coenzyme biochemistry — declining NAD+ levels have been studied in ageing and neurodegeneration research[2] — mitochondrial-peptide signalling, where MOTS-c promoted metabolic homeostasis in mouse models[3], and pituitary GH-axis signalling (sermorelin[5]).
- NAD+ — 500 mg lyophilized vial
- MOTS-C — 10 mg lyophilized vial
- Sermorelin — 5 mg lyophilized vial
- Coenzyme + mitochondrial + GH-axis research coverage
- 10% saving versus buying the three vials separately
Research Applications
Areas of Scientific Investigation
Each compound carries its own line of evidence: NAD+ metabolism during ageing is the subject of a major review literature[1]; in mouse models, MOTS-c was described as an exercise-induced regulator of age-dependent physical decline and muscle homeostasis[4]; and sermorelin was reviewed for use in the diagnosis and treatment of idiopathic growth-hormone deficiency in children[6]. No published study evaluates the three compounds in combination; researchers using them side by side are combining independent lines of evidence.
- Cellular energy and coenzyme metabolism research
- Mitochondrial-peptide and muscle-homeostasis studies
- Growth-hormone axis and pituitary signalling research
- Ageing-biology and physical-decline models
Understanding the Prime Stack: Mechanism of Action
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism and a required substrate for sirtuins and PARP enzymes. Its metabolism and roles in cellular processes during ageing have been comprehensively reviewed[1], and declining NAD+ levels have been studied in ageing, metabolism and neurodegeneration research[2].
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome. In preclinical models it promoted metabolic homeostasis and reduced obesity and insulin resistance in mice[3], and was described as an exercise-induced, mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis in mice[4].
Sermorelin is GHRH(1-29), the shortest fully active fragment of growth-hormone-releasing hormone. In normal men it elicited growth-hormone responses[5], and it was later reviewed for use in the diagnosis and treatment of idiopathic growth-hormone deficiency in children[6].
Together, the three vials give researchers an ageing-biology toolkit: coenzyme biochemistry (NAD+), mitochondrial-peptide signalling (MOTS-c) and pituitary GH-axis signalling (sermorelin). Each is supported by its own line of evidence; no published study evaluates the combination itself. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-13.
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
- Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
- Barron JL, Coy DH, Millar RP. Growth hormone responses to growth hormone-releasing hormone (1-29)-NH2 and a D-Ala2 analog in normal men. Peptides. 1985;6(3):575-577.
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157.
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PRIME Bundle
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Prime
Lab PeptidesTypical
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$198.00$355.00
- ≥99%96%
- 3 vials3 vials
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