HEATWAVE Bundle
The HEATWAVE Bundle is a two-vial melanocortin research stack: PT-141 (bremelanotide) 10 mg and Melanotan II 10 mg — at 10% off the individual vial prices.
PT-141 is a cyclic melanocortin-receptor agonist studied at the MC4R, whose ligand-recognition structure has been resolved[1], and evaluated in two randomised phase 3 trials[3]. Melanotan II is its parent scaffold, a cyclic alpha-MSH analogue used as a pharmacological tool in melanocortin research[4].
Each vial is supplied as a lyophilized powder for reconstitution, and each compound has its own lot-specific third-party certificate of analysis, available on request. Findings above come from preclinical (animal and cell-based) and clinical research on these molecules and are provided as scientific reference for laboratory research only.
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Melanocortin Research Stack
Two Vials, One Receptor Family
The HEATWAVE Bundle pairs two closely related melanocortin-receptor agonists. PT-141 (bremelanotide) is a cyclic heptapeptide targeting the melanocortin-4 receptor, whose ligand-recognition structure has been resolved[1]. Melanotan II is its parent scaffold, a cyclic analogue of alpha-MSH used as a pharmacological tool across melanocortin research[4]. The two molecules differ by a single modification, making the pair a natural model for structure–activity research.
- Two closely related melanocortin-receptor agonists
- PT-141 — bremelanotide, MC4R research peptide
- Melanotan II — cyclic alpha-MSH analogue
- A natural pair for structure–activity research
- Lot-specific third-party COA for each compound
Inside the Bundle
What's in the Stack
The bundle ships as two separate lyophilized vials: PT-141 10 mg and Melanotan II 10 mg. PT-141 is the deamidated metabolite of Melanotan II: in preclinical work, a melanocortin-receptor agonist selectively facilitated sexual solicitation in the female rat[2], and bremelanotide was later evaluated in two randomised phase 3 trials[3]. Melanotan II has been studied across melanocortin pharmacology, from receptor-selectivity scaffolds[4] to rodent appetite models[6].
- PT-141 (bremelanotide) — 10 mg lyophilized vial
- Melanotan II — 10 mg lyophilized vial
- Two melanocortin agonists differing by one modification
- 10% saving versus buying the two vials separately
Research Applications
Areas of Scientific Investigation
Both compounds have been studied in published work: the structural basis of ligand recognition at the melanocortin-4 receptor has been resolved[1]; a synthetic melanotropic peptide initiated erections in men with psychogenic erectile dysfunction in a double-blind crossover study[5]; and bremelanotide was evaluated in two randomised phase 3 trials[3]. No published study evaluates the compounds of this set in combination; researchers using them side by side are combining independent lines of evidence.
- Melanocortin-receptor pharmacology research
- MC4R structure and ligand-recognition studies
- Pigmentation and appetite-signalling models
- Structure–activity relationship research
Understanding the Heatwave Stack: Mechanism of Action
PT-141 (bremelanotide) is a cyclic heptapeptide agonist of melanocortin receptors, with particular research interest in the melanocortin-4 receptor (MC4R), whose ligand-recognition and activation structure has been resolved by cryo-EM[1]. In preclinical work, a melanocortin-receptor agonist selectively facilitated sexual solicitation in the female rat[2], and bremelanotide was evaluated in two randomised phase 3 trials[3].
Melanotan II is a cyclic synthetic analogue of alpha-melanocyte-stimulating hormone and the parent scaffold of PT-141 — PT-141 is its deamidated metabolite. It is used as a pharmacological scaffold in melanocortin-receptor research[4]; in a double-blind crossover study, the synthetic melanotropic peptide initiated erections in men with psychogenic erectile dysfunction[5], and in mice, Melanotan II microinjected into the nucleus accumbens decreased appetitive and consumptive responding for food[6].
Together, the two vials give researchers a matched pair for melanocortin research: the same cyclic scaffold with and without the C-terminal amide, spanning melanocortin-receptor pharmacology, pigmentation and central-signalling research. Each is supported by its own line of evidence; no published study evaluates the two vials of this set in combination. These materials are supplied strictly for laboratory research use.
Scientific Literature
- Zhang H, Chen LN, Yang D, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. 2021;31(11):1163-1175.
- Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc Natl Acad Sci U S A. 2004;101(27):10201-10204.
- Kingsberg SA, Clayton AH, Portman D, et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstet Gynecol. 2019;134(5):899-908.
- Tomassi S, Dimmito MP, Cai M, et al. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. J Med Chem. 2022;65(5):4007-4017.
- Wessells H, et al. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol. 1998;160(2):389-393.
- Eliason NL, et al. Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. Neuropeptides. 2022;96:102289.
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HEATWAVE Bundle
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$103.50$185.00
- ≥99%96%
- 2 vials2 vials
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