NAD+ 500mg (10 Vials)
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme at the center of mitochondrial energy production, sirtuin (longevity-enzyme) activity and DNA repair — and its levels decline with age.
In a randomized, double-blind, placebo-controlled human trial, chronic supplementation with the NAD+ precursor nicotinamide riboside was well tolerated and effectively raised NAD+ metabolism in healthy middle-aged and older adults, with early signals toward lower blood pressure and arterial stiffness[1].
By replenishing the NAD+ pool that fuels sirtuins and PARP DNA-repair enzymes, NAD+ research targets cellular energy, metabolism and aging biology.
Supplied as ten lyophilized-powder vials for reconstitution — a research-quantity pack. Figures above summarize published clinical research on NAD+ precursor supplementation and are provided as scientific reference for laboratory research only.
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Essential Cellular Coenzyme
The Foundation of Cellular Energy and Repair Research
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme involved in over 500 enzymatic reactions throughout the body. Central to cellular energy metabolism, DNA repair, and mitochondrial function, NAD+ has become essential for researchers investigating aging, metabolic health, and cellular resilience. Its levels naturally decline with age, making it a key target for longevity research.
- Essential coenzyme for 500+ enzymatic reactions
- Central role in glycolysis, TCA cycle, and oxidative phosphorylation
- Critical for DNA repair and genomic stability
- Supports mitochondrial biogenesis and function
- High purity (≥98%) for reliable research outcomes
Cellular Mechanisms
How NAD+ Powers Cellular Function and Repair
NAD+ functions as an electron carrier in redox reactions, shuttling electrons through the metabolic pathways that generate ATP — the cell's energy currency. Beyond energy production, NAD+ serves as a substrate for sirtuins (longevity-associated enzymes), PARPs (DNA repair enzymes), and CD38 (immune signaling). This multi-pathway involvement makes NAD+ central to cellular health research.
- Electron carrier for ATP production pathways
- Substrate for sirtuins (SIRT1-7) — key longevity enzymes
- Required for PARP-mediated DNA repair
- Modulates CD38 and immune cell signaling
- Supports circadian rhythm regulation
Research Applications
From Aging Biology to Metabolic Research — Expanding Frontiers
NAD+ has emerged as a cornerstone of longevity and metabolic research. Scientists use it to investigate age-related cellular decline, mitochondrial dysfunction, and metabolic disorders. Its role in sirtuin activation and DNA repair makes it essential for studies exploring healthspan extension, neuroprotection, and cellular rejuvenation.
- Aging biology and longevity pathway studies
- Mitochondrial function and bioenergetics research
- DNA damage response and genomic stability
- Metabolic health and insulin sensitivity modeling
- Neuroprotection and cognitive function studies
- Sirtuin activation and caloric restriction mimetics
The Science Behind Cellular Vitality: Why NAD+ Is Central to Longevity Research
NAD+ stands at the crossroads of cellular metabolism, repair, and aging. As a coenzyme present in every living cell, it participates in over 500 enzymatic reactions — from energy production to DNA maintenance. This ubiquitous involvement makes NAD+ one of the most studied molecules in longevity science.
The research is clear: cellular NAD+ levels decline significantly with age, correlating with reduced mitochondrial function, impaired DNA repair, and decreased sirtuin activity. This decline is now considered a hallmark of aging, driving intense scientific interest in NAD+ replenishment strategies.
NAD+ serves as the essential substrate for sirtuins — a family of enzymes linked to longevity in multiple species. It's also required for PARPs, the enzymes responsible for detecting and repairing DNA damage. Without adequate NAD+, these critical cellular maintenance systems cannot function optimally.
For research teams investigating aging mechanisms, metabolic health, or cellular resilience, NAD+ provides the foundational tool for exploring how cells maintain function over time. Its well-characterized biochemistry and central role in cellular physiology make it indispensable for modern biomedical research.
For research use only. Not for human consumption.
Scientific Literature
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-13.
- Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229.
- Bhasin S, Seals D, Migaud M, Musi N, Baur JA. Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns. Endocr Rev. 2023;44(6):1047-1073.
- Migaud ME, Ziegler M, Baur JA. Regulation of and challenges in targeting NAD+ metabolism. Nat Rev Mol Cell Biol. 2024;25(10):822-840.
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NAD+ 500mg
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