MOTS-C is a mitochondrial-derived peptide (MDP) studied for its role in metabolic regulation, particularly through pathways involving AMPK activation and cellular energy balance.
Research frequently explores its potential in insulin sensitivity, fat oxidation, and exercise-associated adaptations, as well as its relevance in models of aging, stress response, and mitochondrial function.
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Mitochondrial-Derived Peptide
The Exercise Mimetic: A 16-Amino-Acid Metabolic Regulator
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded in the mitochondrial genome. Unlike traditional peptides, MOTS-c functions as a metabolic "stress signal" — activating AMPK pathways to enhance glucose uptake, fat oxidation, and mitochondrial respiration. Its effects resemble those of exercise and caloric restriction at the cellular level, making it central to longevity and metabolic research.
- 16-amino-acid mitochondrial-derived peptide
- Activates AMPK pathway (energy sensing master switch)
- Enhances glucose uptake and insulin sensitivity
- Promotes fat oxidation and mitochondrial function
- Exercise mimetic effects at cellular level
For laboratory research use only. Not for human consumption.
AMPK Activation & Nuclear Signaling
How MOTS-c Bridges Mitochondria and Nucleus
MOTS-c works primarily through AMPK activation via inhibition of the folate cycle, causing accumulation of AICAR (an AMP analog). Under metabolic stress, MOTS-c can also translocate to the cell nucleus — a remarkable property that allows it to directly upregulate antioxidant and stress-response genes. This retrograde signaling from mitochondria to nucleus represents a new paradigm in metabolic regulation research.
- Inhibits folate cycle → AICAR accumulation → AMPK activation
- Translocates to nucleus under metabolic stress
- Upregulates antioxidant and cytoprotective genes
- Enhances glucose uptake independent of insulin pathway
- Modulates mTOR and inflammatory pathways
For laboratory research use only. Not for human consumption.
Research Applications
From Metabolic Dysfunction to Longevity Research
MOTS-c research spans an extraordinary range of applications. Preclinical studies demonstrate effects on insulin resistance, obesity, exercise capacity, osteoporosis, and cardiovascular function. A specific MOTS-c variant has even been linked to exceptional longevity in Japanese populations. This breadth makes MOTS-c one of the most promising compounds in aging and metabolic research.
- Insulin sensitivity and glucose metabolism research
- Obesity and fat metabolism studies
- Exercise capacity and age-related frailty modeling
- Osteoporosis and bone metabolism research
- Cardiovascular and endothelial function studies
- Longevity and healthspan investigations
For laboratory research use only. Not for human consumption.
The Science Behind Mitochondrial Signaling: Why MOTS-c Is Revolutionizing Aging Research
MOTS-c represents a paradigm shift in our understanding of mitochondrial biology. As a mitochondrial-derived peptide (MDP), it functions as a true hormone — leaving the mitochondria to enter the bloodstream and even translocate to the cell nucleus to regulate gene expression. This discovery has opened entirely new avenues in metabolic and longevity research.
The peptide's primary mechanism centers on AMPK activation — the cell's master energy sensor. By inhibiting the folate cycle and causing AICAR accumulation, MOTS-c shifts cells into an energy-efficient mode: enhanced glucose uptake, increased fatty-acid oxidation, improved mitochondrial respiration, and reduced fat storage. These effects mirror what happens during exercise and caloric restriction — two interventions with proven longevity benefits.
Preclinical research has revealed remarkable breadth. In mouse models, MOTS-c reverses age-related insulin resistance in muscle, prevents diet-induced obesity, and enables old mice to run twice as long on treadmill tests. It promotes osteoblast survival and bone formation through TGF-β/SMAD signaling. It improves endothelial function and cardiovascular markers. A specific genetic variant (m.1382A>C) has been linked to exceptional longevity in Japanese populations.
For research teams investigating metabolic disorders, aging biology, exercise physiology, or age-related disease, MOTS-c provides access to a newly discovered signaling system that may fundamentally change how we understand — and potentially intervene in — the aging process.
For research use only. Not for human consumption.
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MOTS-C – 10mg
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Prime Lab PeptidesPeptide Sciences
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$50.00$110.00
- ≥99.874%99.3%
- 10mg10mg
- Free 2-Day Shipping3-10 Business Day
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