News

Melanotan II revealed the central role of MC4 in appetite and energy regulation while exposing the risks of non-selective melanocortin activation. Although unsuitable for therapeutic use, its interaction with MC4 laid the foundation for selective agonist development and continues to shape modern peptide research and metabolic science.

This article examines the use of Sermorelin in experimental models to study physiological hormone rhythms. It focuses on pulsatile growth hormone secretion, circadian regulation, intracellular signaling pathways, and endocrine feedback mechanisms. The discussion is limited to controlled laboratory research and emphasizes mechanistic insights relevant to neuroendocrine investigation rather than applied or translational contexts.

This research-focused overview examines how GHK-Cu regulates fibroblast phenotype, collagen synthesis, and extracellular matrix remodeling in experimental repair models. It explains the peptide’s role in transcriptional reprogramming, collagen and glycosaminoglycan production, myofibroblast resolution, and recovery of damaged fibroblast populations, positioning GHK-Cu as a key signaling regulator in fibrosis and tissue repair research.

This research-focused review examines how Ipamorelin influences pulsatile growth hormone secretion through selective receptor signaling. Drawing on peer-reviewed endocrine literature, it explores pituitary activation, hypothalamic regulation, feedback control, and experimental limitations. The discussion is intended exclusively for researchers studying growth hormone dynamics and peptide-driven signaling models.

Selank is a synthetic peptide studied for its influence on neurochemical signaling during chronic stress exposure. Experimental models suggest its activity intersects with GABAergic modulation, neuroimmune signaling, and stress-adaptive synaptic pathways. This research-focused review examines mechanistic evidence from molecular, cellular, and animal studies without implying therapeutic or clinical use.

Emerging biomarkers provide refined tools for evaluating tesamorelin-driven metabolic responses in research settings. Beyond IGF-1, markers such as hepatic fat fraction, microRNAs, proteomic signatures, myostatin, and inflammatory mediators offer deeper insight into visceral adipose tissue remodeling and lipid flux. This article examines how advanced imaging, proteomics, and molecular profiling enhance the mechanistic understanding of GHRH-associated metabolic modulation.