News

MOTS-c plays a critical role in regulating lipid β-oxidation during exercise-induced energetic stress by activating AMPK, promoting mitochondrial biogenesis, and modulating nuclear gene expression. This article explores how MOTS-c coordinates fatty acid utilization, metabolic flexibility, and systemic lipid handling using molecular, proteomic, and metabolomic evidence from controlled research models.

NAD⁺ homeostasis is central to cellular resilience under chronic pathological stress. This article examines how NAD⁺ availability governs sirtuin activity, mitochondrial integrity, proteostasis, autophagy, and redox balance. It highlights how disruptions in NAD⁺ metabolism accelerate genomic instability, oxidative stress, and metabolic inflexibility in chronic disease research models.

This research-focused review examines how Semax is used in experimental models to study synaptic signaling dynamics under cognitive stress. By analyzing molecular pathways, temporal signaling patterns, and methodological constraints, the article outlines how peptide-based probes support mechanistic investigation without implying therapeutic or functional outcomes.

Experimental research positions cyanocobalamin as a metabolic cofactor essential for DNA synthesis during erythroid cell proliferation. Studies demonstrate that disruption of cobalamin-dependent methionine synthase activity limits nucleotide availability, delays S-phase progression, and selectively impairs nuclear replication in erythroid precursors. This research-focused review examines mechanistic, cellular, and epigenetic evidence defining cyanocobalamin’s role in red blood cell formation.

Melanotan II is a synthetic melanocortin agonist used to investigate MC1R-mediated pigmentation signaling. Experimental models including cell-based systems, animal studies, and pigmentation assays reveal how MC1R activation regulates cAMP pathways, melanin synthesis, and transcriptional control. This blog examines the experimental platforms best suited for MC1R research, providing a framework for melanocortin-focused laboratory investigations.

Sermorelin is a synthetic GHRH analog designed to replicate native hypothalamic peptide signaling with high structural fidelity. Preserving the N-terminal bioactive domain of GHRH, it enables receptor-specific activation, pulsatile growth hormone release, and downstream IGF-1 regulation via JAK2–STAT5 pathways. This blog examines the structural and receptor-level features that allow Sermorelin to integrate physiologically into the hypothalamic–pituitary axis, supporting controlled investigation of growth hormone signaling dynamics.