TB-500 (Thymosin Beta-4) (43 AA is a synthetic peptide fragment consisting of 43 amino acids, widely studied for its role in cell migration and tissue regeneration research.
Scientific interest has focused on its involvement in angiogenesis, actin-binding regulation, and inflammatory response modulation, particularly in musculoskeletal and soft tissue models.
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Full-Length Thymosin Beta-4
The Complete 43-Amino-Acid Peptide for Tissue Regeneration Research
TB-500 is a synthetic 43-amino-acid peptide corresponding to the full sequence of Thymosin Beta-4 (Tβ4) — a naturally occurring protein central to tissue repair and regeneration. Unlike shorter fragments, this complete sequence retains all active regions responsible for actin binding, cell migration, and angiogenesis, making it the definitive tool for comprehensive regenerative research.
- Full 43-amino-acid Thymosin Beta-4 sequence
- Naturally occurring protein involved in tissue repair
- Actin-binding and cell migration properties
- Promotes angiogenesis and wound healing
- High purity for reliable research outcomes
For laboratory research use only. Not for human consumption.
Actin Regulation & Cell Migration
How TB-500 Drives Tissue Repair at the Cellular Level
TB-500 functions primarily through its interaction with G-actin — a key protein that forms the cellular cytoskeleton. By binding to actin, TB-500 promotes cytoskeletal remodeling, enabling cells to migrate toward injury sites. This mechanism drives angiogenesis (new blood vessel formation), accelerates wound closure, and recruits stem and progenitor cells to damaged tissue areas.
- Binds G-actin to promote cytoskeletal remodeling
- Enhances cell migration toward injury sites
- Stimulates angiogenesis and new vessel formation
- Recruits stem and progenitor cells to damaged tissue
- Reduces fibrotic scarring through organized healing
For laboratory research use only. Not for human consumption.
Research Applications
From Musculoskeletal Repair to Cardiac Regeneration Studies
TB-500 has become a cornerstone compound for researchers investigating tissue regeneration across multiple systems. Its established role in angiogenesis and cell migration makes it particularly valuable for musculoskeletal, cardiovascular, and soft tissue research — areas where enhanced healing and reduced fibrosis are primary endpoints.
- Musculoskeletal injury and repair modeling
- Tendon, ligament, and muscle regeneration studies
- Cardiac tissue repair and cardioprotection research
- Wound healing and re-epithelialization studies
- Anti-fibrotic mechanism investigations
- Inflammatory response modulation research
For laboratory research use only. Not for human consumption.
The Science Behind Thymosin Beta-4: Why TB-500 Leads Regenerative Research
TB-500 (Thymosin Beta-4) is a 43-amino-acid peptide that plays a fundamental role in tissue repair and regeneration. Originally identified in the thymus gland, this protein is now known to be expressed in virtually all cell types — functioning as a key regulator of actin dynamics, cell migration, and wound healing processes.
The peptide's mechanism centers on its interaction with G-actin, the monomeric form of the cytoskeletal protein actin. By sequestering G-actin, TB-500 promotes cytoskeletal reorganization — enabling cells to change shape, migrate, and respond to tissue damage. This property is particularly important in angiogenesis, where endothelial cells must migrate and proliferate to form new blood vessels.
Preclinical research has demonstrated TB-500's effects across multiple tissue systems. In wound healing models, it accelerates closure, enhances collagen deposition, and reduces granulation tissue formation. In cardiac models, it shows cardioprotective effects — reducing oxidative damage and supporting tissue regeneration following injury. These diverse applications reflect Thymosin Beta-4's fundamental role in the body's repair processes.
For research teams investigating tissue regeneration, wound healing, or anti-fibrotic mechanisms, TB-500 provides a well-characterized tool with extensive preclinical literature supporting its biological activity across musculoskeletal, cardiovascular, and soft tissue models.
For research use only. Not for human consumption.