Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor, making it one of the most targeted GH-releasing peptides studied to date.
Research frequently examines its role in pulsatile GH release, recovery pathways, and body-composition modulation, with notable selectivity that avoids stimulation of cortisol or prolactin.
This compound is provided as a lyophilized powder.
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Selective GH Secretagogue
The Most Selective Growth Hormone Secretagogue Known
Ipamorelin is a pentapeptide ghrelin receptor agonist that selectively stimulates pulsatile growth hormone release without affecting other pituitary hormones. Unlike older GHRPs, ipamorelin has no measurable effect on ACTH, cortisol, prolactin, FSH, LH, or TSH — making it the "cleanest" GH secretagogue available for research. This exceptional selectivity has made it both a therapeutic candidate and a model compound for understanding receptor specificity.
- Pentapeptide sequence: Aib-His-D-2Nal-D-Phe-Lys-NH₂
- Binds GHSR-1a (ghrelin receptor) with high selectivity
- No effect on ACTH, cortisol, prolactin, FSH, LH, or TSH
- Pulsatile GH release (peak ~40 min, t½ ~2 hours)
- Respects physiologic GH rhythms
For laboratory research use only. Not for human consumption.
Precision GH Signaling
How Ipamorelin Achieves Unmatched Selectivity
Ipamorelin functions as a "precision tap" on the GH axis. By activating GHSR-1a without triggering broader pituitary responses, it produces a brief, physiologic-like GH pulse that returns to baseline — unlike GHRP-6 or hexarelin which act more like "broad faucets" causing neuroendocrine spillover. In animal studies, ipamorelin showed no ACTH/cortisol elevation even at doses >200× its GH ED50.
- Activates GHSR-1a on pituitary somatotrophs
- Synergizes with endogenous GHRH pathway
- Counteracts somatostatin inhibitory tone
- No ACTH/cortisol elevation at >200× GH-effective dose
- Minimal neuroendocrine "noise" vs. older GHRPs
For laboratory research use only. Not for human consumption.
Research Applications
From Bone Protection to Metabolic Research
Ipamorelin research spans multiple therapeutic areas. Studies demonstrate its ability to counteract glucocorticoid-induced bone loss (4× increase in bone formation), improve nitrogen balance, potentiate insulin release, and accelerate GI recovery. Its selectivity also makes it valuable as a diagnostic probe — radiolabeled ipamorelin can image ghrelin receptor expression in cancer and heart failure research.
- Bone health: Counteracts glucocorticoid-induced bone loss
- Muscle preservation: Improves nitrogen balance
- Metabolic research: Potentiates insulin release
- GI function: Accelerates post-operative recovery
- Diagnostic imaging: PET probe for GHSR-1a expression
For laboratory research use only. Not for human consumption.
The Science Behind Selective GH Stimulation: Why Ipamorelin Is the Reference Standard
Ipamorelin represents the pinnacle of selective growth hormone secretagogue design. As a pentapeptide ghrelin receptor agonist, it binds GHSR-1a to trigger pulsatile GH release with a profile that closely mimics physiologic secretion — peak at approximately 40 minutes, terminal half-life of about 2 hours, then return to baseline. This respects the body's natural GH rhythms rather than flattening them.
What sets ipamorelin apart is its unprecedented selectivity. Classic GHRPs like GHRP-6 and hexarelin stimulate GH but also raise ACTH, cortisol, and prolactin — especially at higher doses or with intravenous administration. Ipamorelin showed no ACTH or cortisol elevation in animal studies even at doses exceeding 200 times its GH-effective dose. This "clean" profile eliminates endocrine noise in experimental designs and opens doors for chronic administration studies.
Research applications are remarkably diverse. In glucocorticoid-treated rats, ipamorelin produced a 4-fold increase in bone formation while also increasing bone mineral density systemically. It improves nitrogen balance and reduces muscle catabolism — addressing two of the most treatment-limiting side effects of corticosteroid therapy. In diabetic models, ipamorelin potentiates insulin release through indirect stimulation of pancreatic calcium channels.
Beyond therapeutics, ipamorelin's high receptor affinity makes it valuable as a diagnostic research tool. Radiolabeled derivatives can image GHSR-1a expression — relevant in cancer (where ghrelin receptors are often upregulated) and cardiovascular research. For teams studying GH physiology, receptor selectivity, or musculoskeletal metabolism, ipamorelin provides the cleanest available tool.
For research use only. Not for human consumption.
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Ipamorelin – 10mg
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Prime Lab PeptidesPeptide Sciences
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$52.00$80.00
- ≥99.874%99.3%
- 10mg10mg
- Free 2-Day Shipping3-10 Business Day
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