{"product":{"id":9304105713826,"title":"5-Amino-1MQ – 10mg","body_html":"\u003cdiv class=\"plp-desc-rt\"\u003e\n\u003cstyle\u003e\n.plp-desc-rt{font-family:var(--font-body-family,Helvetica,Arial,sans-serif);color:rgba(18,18,18,.7)}\n.plp-desc-rt p{margin:0 0 15px;font-size:15.5px;font-weight:400;line-height:1.7}\n.plp-desc-rt strong{color:#0e2a44;font-weight:600}\n.plp-desc-rt em{color:rgba(18,18,18,.5)}\n.plp-desc-rt sup{line-height:0}\n.plp-desc-rt sup a{font-size:11px;font-weight:600;color:#2279be;text-decoration:none;padding:0 1px}\n.plp-desc-rt sup a:hover{color:#0e2a44}\n\u003c\/style\u003e\n\u003cp\u003e5-Amino-1MQ (5-amino-1-methylquinolinium, also written 5A1MQ) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), supplied for laboratory research. Unlike the peptides that make up most of this catalog, it is a compact quinolinium compound rather than an amino-acid chain.\u003c\/p\u003e\n\u003cp\u003eNNMT transfers a methyl group from S-adenosyl-L-methionine to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine. Because nicotinamide also feeds the NAD+ salvage pathway, the enzyme sits at the junction of methyl-donor and NAD+ metabolism, which is what makes it an object of study in metabolic enzymology. Reported selectivity assays for this inhibitor class describe no inhibition of other SAM-dependent methyltransferases or of NAD+ salvage enzymes.\u003c\/p\u003e\n\u003cp\u003ePublished work is preclinical throughout. In cultured adipocytes, inhibitors of this scaffold lower intracellular 1-methylnicotinamide, raise NAD+ and SAM, and suppress lipogenesis. Rodent studies report elevated NNMT expression in white adipose tissue and liver in diet-induced obesity models, and effects of knockdown on adipose NAD+ and SAM, polyamine flux, histone H3K4 methylation and adipocyte oxygen consumption. Genetic Nnmt-deletion studies report sex- and diet-dependent outcomes that only partly overlap with the inhibitor literature, and no human clinical data are published.\u003c\/p\u003e\n\u003cp\u003eThis product is intended for laboratory research use only. It is not for human or veterinary use, diagnostic use, or any form of consumption.\u003c\/p\u003e\n\u003c\/div\u003e","vendor":"Prime Lab Peptides","product_type":"","created_at":"2026-08-17T08:31:30-04:00","handle":"5-amino-1mq-10mg","updated_at":"2026-10-01T15:23:25-04:00","published_at":"2026-08-17T09:20:41-04:00","template_suffix":"5-amino-1mq","published_scope":"global","tags":"","variants":[{"id":47540251000994,"product_id":9304105713826,"title":"Default Title","price":"45.00","sku":"10AM","position":1,"compare_at_price":"60.00","fulfillment_service":"manual","inventory_management":"shopify","option1":"Default Title","option2":null,"option3":null,"created_at":"2026-08-17T08:31:30-04:00","updated_at":"2026-10-01T15:23:25-04:00","taxable":true,"barcode":"","grams":0,"image_id":null,"weight":0.0,"weight_unit":"lb","requires_shipping":true,"quantity_rule":{"min":1,"max":null,"increment":1},"price_currency":"USD","compare_at_price_currency":"USD","quantity_price_breaks":[]}],"options":[{"id":null,"product_id":9304105713826,"name":"Title","position":1,"values":["Default Title"]}],"images":[{"id":36908912705698,"product_id":9304105713826,"position":1,"created_at":"2026-08-17T08:31:30-04:00","updated_at":"2026-10-01T15:23:25-04:00","alt":"5-Amino-1MQ – 10mg","width":1600,"height":1600,"src":"https:\/\/primelabpeptides.com\/wp-content\/themes\/primelab\/media.php?f=files\/primelab-5-amino-1mq-10mg.webp","variant_ids":[]},{"id":37268723630242,"product_id":9304105713826,"position":2,"created_at":"2026-08-17T08:31:30-04:00","updated_at":"2026-10-01T15:23:25-04:00","alt":"Certificate of Analysis - 5-Amino-1MQ 10mg - lot 042758316AMQ - 99.95% purity - Freedom Diagnostics","width":2550,"height":3300,"src":"https:\/\/primelabpeptides.com\/wp-content\/themes\/primelab\/media.php?f=files\/primelab-coa-5-amino-1mq-10mg-lot-042758316AMQ.webp","variant_ids":[]}],"image":{"id":36908912705698,"product_id":9304105713826,"position":1,"created_at":"2026-08-17T08:31:30-04:00","updated_at":"2026-10-01T15:23:25-04:00","alt":"5-Amino-1MQ – 10mg","width":1600,"height":1600,"src":"https:\/\/primelabpeptides.com\/wp-content\/themes\/primelab\/media.php?f=files\/primelab-5-amino-1mq-10mg.webp","variant_ids":[]}}}